Gene information
Official symbol ADRB1
Official full name adrenoceptor beta 1
Gene type protein-coding gene
Chromosome10q25.3
Previous symbolADRB1R
Gene familyAdrenoceptors
Resources
Entrez Gene 153
HGNC HGNC:285
Ensembl ENSG00000043591
Vega OTTHUMG00000019079
UCSC uc001lba.4
GO terms: 38 records
GO Description Category LogP Number of genes Detail
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0004935 adrenergic receptor activity GO Molecular Functions -7.55914528 5 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008227 G protein-coupled amine receptor activity GO Molecular Functions -5.63918224 7 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009409 response to cold GO Biological Processes -5.06845562 11 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010460 positive regulation of heart rate GO Biological Processes -6.02792411 9 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031690 adrenergic receptor binding GO Molecular Functions -4.18483678 6 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0042311 vasodilation GO Biological Processes -18.7593927 16 More
GO:0042596 fear response GO Biological Processes -3.60825621 7 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045777 positive regulation of blood pressure GO Biological Processes -5.41560423 6 More
GO:0045823 positive regulation of heart contraction GO Biological Processes -10.6953794 15 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0071875 adrenergic receptor signaling pathway GO Biological Processes -8.98205881 11 More
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO Biological Processes -9.78130162 11 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098685 Schaffer collateral - CA1 synapse GO Cellular Components -5.81792293 14 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 83 records
Drug name Interaction type Source PMID View
acebutolol antagonistpartial agonist DTCTdgClinicalTrialTENDPharmGKBTTD 2903243245374425689351626814811752352 view
acebutolol hydrochloride antagonist ChemblInteractions view
alprenolol antagonist DTCTdgClinicalTrialTEND 1252207829032432828119760634876786771043349611752352 view
amiodarone negative modulatorinhibitorantagonist TdgClinicalTrialTEND 16725921208399110049740 view
anisodamine TTD view
arbutamine agonist TdgClinicalTrialTENDTTD 87231691713928417016423 view
atenolol antagonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 15864115206432541586103716815314290324320352314127097261292180715735607180754641284413493003151762861111752352226172241178747717496726145345242131189712065078145022781091301620235788 view
betaxolol antagonist DTCTdgClinicalTrialTENDTTD 290324320771801751302912181453289146311752352 view
betaxolol hydrochloride antagonist ChemblInteractions view
bethanidine antagonist TTD 6114720681240611752352 view
bevantolol antagonist TdgClinicalTrialTEND 256862928582366148733176286112888789 view
bisoprolol antagonist DTCTdgClinicalTrialTENDPharmGKBTTD 147571451586103729032431280737167667516913661632505011752352 view
bisoprolol fumarate antagonist ChemblInteractions view
bretylium TTD view
bucindolol TdgClinicalTrialPharmGKBTTD 15864115206432541586103716815314203523141270972612921807157356071807546412844134226172241749672614534524213118971450227820235788 view
budiodarone TdgClinicalTrial view
bufuralol antagonist DTC 290324337605 view
bunitrolol DTC 2903243 view
bunolol DTC 2903243 view
bupranolol antagonist DTC 290324319439807 view
carteolol partial agonist DTCTdgClinicalTrialTENDTTD 161600852903243108648811552610711752352 view
carteolol hydrochloride antagonist ChemblInteractions view
carvedilol antagonist TdgClinicalTrialChemblInteractionsTENDPharmGKB 15864115206432541586103725757621681531420352314171233579082561270972625771441292180715735607180754641284413422617224174967261453452421311897145022782764387420235788 view
carvedilol phosphate antagonist ChemblInteractions view
celiprolol antagonist DTC 1863606929032431738446217141277 view
chembl111201 TTD view
desipramine other/unknown TdgClinicalTrialTEND 1239387615093822873074378168638741184 view
dichloroisoproterenol DTC 2903243 view
digoxin PharmGKB 22543981 view
dipivefrin TTD view
dipivefrin hydrochloride agonist ChemblInteractions view
dobutamine agonist TdgClinicalTrialTENDPharmGKBTTD 120985821556487716325050117523521175357716627864 view
dobutamine hydrochloride agonist ChemblInteractions view
dopamine PharmGKB view
dopamine hydrochloride agonist ChemblInteractions view
dronedarone antagonist TdgClinicalTrialTEND 1738966723997577 view
droxidopa agonist ChemblInteractions 94648971806441719110970 view
epinephrine agonist TdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 175415571762277484012051175235210085337 view
epinephrine bitartrate agonist ChemblInteractions view
esmolol antagonist TdgClinicalTrialTENDTTD 2894187795753219759952568748117523527612051 view
esmolol hydrochloride antagonist ChemblInteractions view
hydrochlorothiazide PharmGKB 158641291455396216109321 view
hydroxyamphetamine hydrobromide agonist ChemblInteractions view
indacaterol agonist DTC view
isoetharine agonist TdgClinicalTrialTEND 1715777915917856176286111697369117329986 view
isoproterenol agonist TdgClinicalTrialTENDPharmGKBTTD 159085121473404610722117523522764387416038799 view
isoproterenol hydrochloride agonist ChemblInteractions view
labetalol antagonist TdgClinicalTrialTEND 1987981863556648104240615182472868471175235216873677684671 view
labetalol hydrochloride antagonist ChemblInteractions view
levobetaxolol antagonist TTD view
levobetaxolol hydrochloride antagonist ChemblInteractions view
levobunolol antagonist TdgClinicalTrialTENDTTD 11572462108648811351412289146379281822892662 view
levobunolol hydrochloride antagonist ChemblInteractions view
ly377604 antagonist ChemblInteractions view
mephentermine sulfate agonist ChemblInteractions view
mepindolol DTC 2903243 view
metipranolol antagonist TdgClinicalTrialTENDTTD 28852441296772228950371713928417016423 view
metipranolol hydrochloride antagonist ChemblInteractions view
metoprolol antagonist DTCTdgClinicalTrialTENDPharmGKBTTD 1144847415864115206432541586103716815314290324320352314127097261292180715735607180754641284413412679135117523522261722417496726145345242131189714502278109130162023578816402084 view
metoprolol succinate antagonist ChemblInteractions view
muraglitazar PharmGKB 18794727 view
nadolol antagonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 2903243106064401354084791253979810091043349611752352 view
nebivolol antagonist TdgClinicalTrialTENDTTD 117523521766173516961165 view
nebivolol hydrochloride antagonist ChemblInteractions view
norepinephrine agonist DTCPharmGKBTTD 2903243946489718064417123835751175235219110970 view
norepinephrine bitartrate agonist ChemblInteractions view
oxprenolol antagonist TdgClinicalTrialTENDTTD 620296061244922871880117523521713928417016423 view
oxprenolol hydrochloride antagonist ChemblInteractions view
penbutolol partial agonistantagonist TdgClinicalTrialTENDTTD 117384816755764112241952189902 view
penbutolol sulfate antagonist ChemblInteractions view
pindolol partial agonistagonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 146084562907348290324321487268884690117523521687398 view
practolol antagonist DTCTdgClinicalTrialTENDTTD 29032432871880652427830388285711611752352 view
propafenone hydrochloride antagonist ChemblInteractions view
propranolol antagonist DTCTdgClinicalTrialTENDTTD 1523684329032431475770317628611175726941175235216177222 view
propranolol hydrochloride antagonist ChemblInteractions view
salmeterol inverse agonist DTC 14730417 view
sotalol antagonist DTCTTD 80953972903243117523521181538119259968286568515060759 view
sotalol hydrochloride antagonist ChemblInteractions view
spironolactone PharmGKB 22543981 view
tertatolol DTC 2903243 view
timolol antagonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 108705192903243163150321043349611752352886432112221524 view
timolol maleate antagonist ChemblInteractions view
ziprasidone TEND view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
NM_000684.3:c.1165G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Iwai C et al. Am Heart J. 2003
NM_000684.3:c.1165G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Song YL et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
NM_000684.3:c.1165G>C genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Yilmaz A et al. J Clin Lab Anal. 2009
NM_000684.3:c.1165G>C genomics left ventricular hypertrophy[prognosis (bad)] acute myocardial infarction Hakalahti AE et al. Cardiovasc Diabetol. 2010
NM_000684.3:c.1165G>C genomics left ventricular dysfunction[prognosis (bad)] acute ST elevation myocardial infarction McLean RC et al. Cardiovasc Drugs Ther. 2011
NM_000684.3:c.145A>G genomics myocardial infarction[diagnosis] myocardial infarction Xia K et al. Gene. 2017
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